Are all the miRBase-registered microRNAs true?

miRBase: annotating high confidence microRNAs using deep sequencing data

We describe an update of the miRBase database (http://www.mirbase.org/), the primary microRNA sequence repository. The latest miRBase release (v20, June 2013) contains 24 521 microRNA loci from 206 species, processed to produce 30 424 mature microRNA products. The rate of deposition of novel microRNAs and the number of researchers involved in their discovery continue to increase, driven largely...

The miRBase Sequence Database

Evolution of microRNAs and their targets: are all microRNAs biologically relevant?

MicroRNAs (miRNAs) are defined by their precise processing from a longer stem-loop precursor and by their subsequent ability to direct the regulation of target RNAs distinct from the miRNA precursor. Several lines of evidence suggest that miRNAs arose at least twice during eukaryotic evolution from an ancestral, pan-eukaryotic small RNA producing molecular machinery, though alternative scenario...

True Trees Are Dense

We show that any compact, connected set K in the plane can be approximated by the critical points of a polynomial with two critical values. Equivalently, K can be approximated in the Hausdorff metric by a true tree in the sense of Grothendieck’s dessins d’enfants. Mathematics Subject Classification 30C62

miRBase: tools for microRNA genomics

miRBase is the central online repository for microRNA (miRNA) nomenclature, sequence data, annotation and target prediction. The current release (10.0) contains 5071 miRNA loci from 58 species, expressing 5922 distinct mature miRNA sequences: a growth of over 2000 sequences in the past 2 years. miRBase provides a range of data to facilitate studies of miRNA genomics: all miRNAs are mapped to th...